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Family Fabaceae
Tiagkot
Archidendron clypearia (Jacl) I.C.Nielsen
MONKEY-POD
Hou er huan

Scientific names Common names
Abarema clypearia (Jack) Kosterm.            Tiagkot (Tagalog)
Adenanthera ossea Mannetti            Greater-grasshopper tree (Engl.)
Albizia clypearia (Jack) Kurz            Monkey-pod (Engl.)
Feuilleea clypearia (Jack) Kuntze             
Inga clypearia Jack             
Pithecellobium clypearia (Jack) Benth.             
Accepted infraspecifics (4)  
Archidendron clypearia subsp. clypearia (28 synonyms)  
Abarema angulata (Benth.) Kosterm. . . .         
Pithecellobium subacutum Benth.       
Archidendron clypearia var. montanum (Benth.) Gang. & Chak.  
Abarema clypearia f. montana (Benth.) Kosterm. . . .         
Pithecellobium variegatum Blume ex Miq.       
Archidendron clypearia subsp. subcoriaceum (Thwaites.) Niels.  
Abarema subcoriacea (Thwautes) Kosterm.  . .          
Pithecellobium anamalayanum Bedd.      
Archidendron clypearia var. velutinum (Merr. & LM Perry) Niels.  
Abarema clypearia subsp. velutinum Merr. & L.M.Perry        
Pithecellobium clypearia var. velutinum Merr. & L.M.Perry      
Archidendron clypearia is an accepted species. KEW: Plants of the World Online

Other vernacular names
CHINA: Hou er huan.
INDIA: Rhasahu, Thorekana (Assamese); Attha berantha, Mazhavaka, Pulivaka (Malayalam); Malai-vagai, Mazhavagai (Tamil).
MALAY: Petai belalang, Jering monyet.
OTHERS: Chahar.

Gen info
- Archidendron is a genus of flowering plants in the pea family, Fabaceae, which includes 98 species ranging from India through Indochina, souther China, Taiwan, Malesia, and Papuasia to Queensland and New South Wales. (2)
- Etymology: The genus name Archidendon derives from Greek words archi, primitive, and dendron, tree. The species name clypearia derive from Lain, referring to a small round Roman shield, a reference to the use of the wood in making sheaths of weapons. (3)

Botany
Trees, to 10 m tall. Branchlets angulate, densely yellow tomentose. Leaf petiole 4-angulate; leaf rachis and base of petiole with glands; glands flat or hollow; pinnae (3 or)4 or 5(-8) pairs, densely yellow tomentose, lowermost pinna with 3-6 pairs of leaflets, uppermost one with 10-12 pairs of leaf­lets; leaflets subsessile, adaxially shiny, oblique, rhombic-trape­zoid, 1-7 × 0.7-3 cm, upper one largest, downward smaller, leathery, both surfaces slightly brown pubescent, base very unequally sided. Corymbs several flowered, arranged in termi­nal or axillary panicles. Flowers pedicellate. Calyx campan­ulate, 1-3 mm, 5-toothed, calyx and corolla densely brown vil­lous. Corolla white or yellowish, 4-5 mm; lobes lanceolate. Sta­mens ca. 2 × as long as corolla, staminal tube equaling corolla tube. Ovary stipitate, hairy. Legume twisted, 1-1.5 cm wide, margin constricted between seeds. Seeds 4-10, black, ellip­soidal or broadly ellipsoidal, ca. 1 cm; testa wrinkled when dry. (Flora of China)

Growth form: A much-branched and medium-sized tree up to 22 m tall. Foliage: Alternate, long-stalked, bipinnate leaves possess 3–14 pairs of leaflets. The lowermost leaflet bears 3–6 pairs of leaflets, while the uppermost bears 8–14 pairs of papery leaflets that are opposite, diamond-shaped, and 1–7.6 by 0.7–3.8 cm. The leaflets gradually decrease in size towards the lowermost leaflet.
Flowers
: Stalked flowers are white to yellowish, and develop up to 10 together in clusters. The clusters are arranged in shoots more than 30 cm-long, at the older leaf’s angles, or on leafless portions of twigs.
Fruits: Fruits are orange and red, 1–1.5 cm wide, spirally twisted legumes that contain 4–10 seeds. Its seeds are black, oval, up 1 cm wide, and wrinkled when dry. (3)

Distribution
- Native to the Philippines.
- Also native
to Andaman Is., Assam, Bangladesh, Borneo, Cambodia, China South-Central, China Southeast, East Himalaya, Hainan, India, Jawa, Laos, Malaya, Maluku, Myanmar, Nepal, New Guinea, Nicobar Is., Sri Lanka, Sulawesi, Sumatera, Taiwan, Thailand, Vietnam. (1)

Constituents
- Study of methanol extract of A. clypearia isolated six compounds, including 1-octacosanol, docosenoic acid, daucosterol, methyl gallate, quercitrin and (−)-7-O-galloyltricetiflavan. (see study below) (4)
- Phytochemical analysis of methanol extract of leaves and twigs isolated two new chalcones, clypesides A-B (1,2), 13 flavonoid derivatives (3-15). (see study below) (8)
- Study of leaves and twigs isolated five undescribed phenolics, pithecellobiumin C-G, along with thirteen known ones. (see study below) (10)
- Study of leaves and twigs of  Ac reports on the isolation of a new dilignan, archidendronin A (1), along with one known sesquilignan (2). (see study below) (11)
- Chromatographic analysis ofchloroform extract yielded four compounds i.e., daucosterol,
1-octacosanol, docosenoic acid, and methyl gallate. (see study below) (14)
- Study of leaves and twigs isolated three pairs of furolactone-type lignan enantiomers, including two new compounds (1R,5S,6S)-Kachiranol (1a) and (1S,5R, 6R)-Kachiranol (1b) and four known compounds. (see study below) (15)

Properties
- Studies have suggest xanthine oxidase inhibitory, antibacterial, antidiabetic, anti-inflammatory, ß-amyloid aggregation inhibitory, sEH inhibitory, sucrase inhibitory, antioxidant, antibacterial, antioxidant properties.

Parts used
Stem bark, leaves, twigs, peels.

Uses

Edibility
- No information found on edibility.
Folkloric
- No reported folkloric medicinal use in the Philippines.
- Decoction of stem bark used as poultice for abscesses. (3)
- Decoction of leaves used as bath water for treatment of scabies. Dried leaves used for wound healing.
Others
- Wood: Use for making weapon sheaths, boxes, coffins, knife and tool handles, joinery, and various light construction.
- Bark:
Use for making hair shampoo, and tanning fishing nets. (16)

- Leaves: Use for coloring and tannin of rattan. Reported used as cattle poison. (3)
- Staining: Leaves and bark used to stain cloth black. (16)
- Fuel: Wood can be used as fuel.

Studies
Xanthine Oxidase Inhibitors:
Study screened 311 methanol extracts form 301 Vietnamese herbs were screened for xanthine oxidase (XO) inhibitory activity and isolated XO inhibitor(s) from the most active plant. Extracts of Archidendron clyperaria, Smilax poilanei, Linociera ramiflora and Passiflora foetida exhibited greatest potency with IC50 values < 30 µg/mL. Extract of A. clypearia isolated six compounds, including 1-octacosanol, docosenoic acid, daucosterol, methyl gallate, quercitrin and (−)-7-O-galloyltricetiflavan. The compound (-)-7-O-galloyltricetiflavan showed most potent XO inhibitory activity with IC50 of 25.5 µmol/L. (4)
Antibacterial / Antidiabetic: Study systematically evaluated the antibacterial and antidiabetic components of A. clypearia using a combination of analytical methods. Network pharmacology and molecular docking were used to predict the main target components of A. clypearia and enzyme inhibition sites of α-amylase and α-glucosidase. P15, P16, and P20 were found to be the antibacterial and antidiabetic active components. The inhibitory effect of P15 (7-O-galloyltricetiflavan) on six bacterial species may be mediated through the lipid and atherosclerosis pathway, prostate cancer, adherens junctions, and targets such as SRC, MAPK1, and ASKT1. Molecular docking showed 7-O-galloyl-tricetiflavan and 7,4'-di-O-galloyltricetiflavan (P16/P20) can bind to α-amylase and α-glucosidase pockets with binding energies lover than -6 kcal/mol. Study provides guidance for the development of antibacterial and antidiabetic products based on A. clypearia. (5)
Anti-Inflammatory: Study evaluated the anti-inflammatory effects of a 95% methanol extract (Ac-ME) on the AP-1 activation pathway, which play a critical role in the production of prostaglandin (PG)-E2 in RAW264.7 cells and peritoneal macrophages and in induction of acute gastritis caused by HCl/EtOH. The Ac-ME reduced nuclear levels of total and phospho-forms of c-Jun, FRA-1, and ATF-2. The extract suppressed both production of PGE2 in lipopolysaccharide (LPS)-activated RAW264.7 and peritoneal macrophage cells and PGE2-dependent induction of gastritis lesion under HCl/EtOH exposure. HPLC analysis showed quercetin, which inhibits PGE2 production is an active component in AcME. Study suggests Ac-ME is an ethnomedicinal remedy with an IRAK1/p38/AP-1 targeted inhibitory property. (6)
Anti-Inflammatory on DSS-Induced Colitis: Study evaluated the anti-inflammatory effects of 95% Ac-ME on the production of inflammatory mediators in RAW264.7 cells and peritoneal macrophages and on symptoms of colitis in mouse induced by dextran sodium sulphate (DSS). The Ac-ME dose-dependently suppressed the secretion of nitric oxide (NO) and prostaglandin-E2 (PGE2) from RAW264.7 cells and peritoneal macrophages stimulated by LPS. The AcME clearly reduced mRNS expression of iNOS, COX-2, and TNF-α by blockade of NF-kB activation and upstream signaling events containing protein tyrosine kinase activities of Src and Syk and the formation of molecular signaling complex including p85. Results showed remarkable inhibition of DSS-induced colitis through suppression of Src and IkBα phosphorylation. (7)
sEH Inhibitors / Flavonoids / Leaves and Twigs: sEH (soluble epoxide hydrolase) is a member of the epoxide hydrolase family and is found primarily in the cytosol and peroxisomes of mammalian tissues including the liver, intestines and vascular tissues. Study of methanolic extract of leaves and twigs of Ac significantly inhibited sEH (soluble epoxide hydrolase) in vitro. Phytochemical analysis of water layer isolated two new chalcones, clypesides A-B (1,2), 13 flavonoid derivatives (3-15). All the flavonoid derivatives inhibited sEH (soluble epoxide hydrolase) enzymatic activity in a dose-dependent manner, with IC50s ranging from 10.0 to 30.1 µM. Kinetic analysis of compounds 4, 8-10, 12, 13, and 15 revealed compounds 8-10 were non-competitive, 4, 13 and 15 were mixed type, and 12 competitive inhibitor. Results suggest the flavonoid derivatives from Ac are potential sEH inhibitors. (8)
Anti-ß-Amyloid Aggregation Activity / Triterpenes / Leaves and Twigs: Study of twigs and leaves isolated a new triterpene and five known compounds. The isolated compounds were evaluated for inhibition of ß-amyloid aggregation by ThT-based fluorometric assay. Compound 3 (67.8%) and 6 (77.7%) exhibited higher inhibitory activity than positive (48.0%). (9)
Neuroprotective / Leaves and Twigs: Study of leaves and twigs isolated five undescribed phenolics, pithecellobiumin C-G, along with thirteen known ones. The compounds were tested for neuroprotective activities against H2O2-induced injury in human neuroblastoma SHJ-SY5Y cells by MTT assay. Pithecellobiumin C-E exhibited noticeable neuroprotective effect, preventing cell death through inhibition of apoptosis induction. Flow cytometric studies showed the compounds could attenuate reactive oxygen species (ROS) level and mitochondrial dysfunction in SH-SY5Y cells. (10)
Dilignan / Anti-ß-Amyloid Aggregation Activity / Leaves and Twigs: Study of leaves and twigs of  Ac reports on the isolation of a new dilignan, archidendronin A (1), along with one known sesquilignan (2). Inhibitory activity on Aß1-42 aggregation was screened by ThT assay with curcumin as positive control. Compounds 1 and 2 showed inhibition rate of 60.0% and 64.4% at 20 µM, respectively. (11)
Anti-Inflammatory on AP-1 Activation Pathway: Study evaluated the anti-inflammatory mechanism of 95% methanol extract (AcME) on AP-1 activation pathway. Results showed AcME reduced nuclear levels of total and phospho-forms of c-Jun,   FRA-1, and ATF-2. The AcME suppressed both production of PGE2 in LPS-activated RAW264.7 and and peritoneal macrophage cells and PGE2=dependent induction of gastritis lesion under EtOH/HCl exposure. The AcME blocked the enzyme activity of IRAK1, indicating the enzyme is an inhibitory target of AcME and is involved in the suppression of the AP-1 pathway. HPLC analysis showed quercetin, which inhibits PGE2 production, is an active component in AcME. (12)
Inhibition of Intestinal Sucrase / Antidiabetic Potential / Leaves and Twigs: A methanolic extract of leaves and twigs of A. clypearia significantly inhibited rat intestinal sucrase in vitro. A phytochemical analysis of aqueous layer isolated 14 compounds (1-14). The ME and water layer at concentration of 3.0 mg/mL showed potent sucrase inhibitory activity with 67.7 and 95.33% inhibition, respectively.  Compounds 6, 7, and 10 (1.0 mM) showed potent sucrase inhibition (88.36, 81.57, and 66.32 % inhibition). Results suggest the sucrase inhibitory activity may provide novel opportunity for a new class of antidiabetic agents. (13)
Antioxidant / Aerial Parts: In vitro study of methanol extract for antioxidant activity on isolated liver  cells of mice showed ED50 of 2.18 µg/mL compared to curcumin at 1.87 µg/mL. Chromatographic analysis yielded four compounds from the chloroform extract i.e., daucosterol, 1-octacosanol, docosenoic acid, and methyl gallate. All four compounds showed high antioxidant activity, with methyl gallate showing highest one.  (14)
Enantiomeric Furolactone-Type Lignan / Anti-ß-Amyloid Aggregation Activity: Study of leaves and twigs isolated three pairs of furolactone-type lignan enantiomers, including two new compounds   (1R,5S,6S)-Kachiranol (1a) and (1S,5R, 6R)-Kachiranol (1b) and four known compounds. All compounds were evaluated for inhibitory effects on ß-amyloid aggregation by ThT assay. Compound 1b showed 71.1% inhibitory activity, higher than positive control (61.0%) and other compounds. (15)
Amelioration of Imiquimod-Induced Psoriasis / Aerial Parts: Study sought to clarify the protective effects of ethanol fraction of water extract (ESW) of Pithecellobium clypearia against psoriasis-like skin inflammation induced by imiquimod (IMQ) in mice with efficacy indexes and target tissue (spleen and serum) metabolomics. The ESW was composed mainly of gallic acid, ethyl gallate, quercitin, 7-O-galloyltricetiflavan, quercetin, and myricetin by UHPLC-MS/MS analysis. ESW distinctly improved IMQ-induced psoriasis in mouse by reducing PASI score, alleviating tissue damage, restoring spleen index, and inhibiting proliferating cell nuclear antigen (PCNA) expression in psoriasis-like skin tissue. Results showed ESW had obvious antipsoriasis effect on IMQ-induced psoriasis in mice, which may be attributed to regulation of dysfunction of differential biomarkers and related pathways. (17)
Comparative Study / Radical Scavenging /  Phenolic and Flavonoid Contents / Antibacterial / Peels: Study evaluated the radical scavenging activity, flavonoid and phenolic contents of of Archidendron clypearia peels and 13 other medicinal plants and dried tea leaves (green tea, oolong tea and black tea). The aqueous extract of A. clypearia showed growth inhibition of all tested enteric pathogenic bacteria (E. coli, S. typhi, S. dysenteriae. S. aureus, and V. cholera). On radical scavenging activity against DPPH free radicals, the aqueous and ethanolic extracts of A. clypearia showed greatest antioxidant activity to inhibit DPPH radicals with values of 138.48 and 233.33 mg GAE/g extract, total phenolic content of 109.14 and 123.70 mg GAE/g extract, and total flavonoid content of238.54 and 12.03 mg QUE/g extract, respectively, compared to green tea at 80.38, 116.15, 12.86, 101.57, 105.42 and 409.42, respectively.

Availability
Wild-crafted.

July 2024

                                                 PHOTOS / ILLUSTRATIONS
IMAGE SOURCE: Fabaceae : Archidendron clypearia / Leaf / Copyright © 2018 by P B Pelser & J F Barcelona (contact: pieter.pelser@canterbury.ac.nz) [ref. DOL131943] / Non-Commercial Use  / Click on image or link to go to source page / Phytoimages.siu.edu
OTHER IMAGE SOURCE: Fabaceae : Archidendron clypearia / Fruit / Copyright © 2015 by P B Pelser & J F Barcelona (contact: pieter.pelser@canterbury.ac.nz) [ref. DOL102515] / Non-Commercial Use  / Click on image or link to go to source page / Phytoimages.siu.edu
OTHER IMAGE SOURCE: Fabaceae : Archidendron clypearia / Fruit / Copyright © 2011 by Leonardo L Co B [ref. DOL26266] / Non-Commercial Use  / Click on image or link to go to source page / Phytoimages.siu.edu

Additional Sources and Suggested Readings
(1)
Archidendron clypearia / KEW: Plants of the World Online
(2)

Archidendron / Wikipedia
(3)
Archidendron clypearia (Jack) I.C.Nielsen var. clyperia / National Parks: FLORA & FAUNA WEB
(4)
Xanthine oxidase inhibitors from Archidendron clypearia (Jack.) I.C. Nielsen: Results from systematic screening of Vietnamese medicinal plants / Nguyen Thuy Duong, Pham Duc Vinh, Phuong Thien Thuong, Nguyen Thi  Hoai, Le Nguyen Thanh, Tran The Bach, Nguyen Hai Nam, Nguyen Hoang Anh / Asian Pacific Journal of Tropical Medicine,  2017; 10(6): pp 549-556 / DOI: 10.1016/j.apjtm.2017.06.002
(5)
Discovery, Validation, and Target Prediction of Antibacterial and Antidiabetic Components of Archidendron clypearia Based on a Combination of Multiple Analytical Methods / Wenduo Ji, Lixia Gu, Xuezhe Zou, Hong Deng et al / Molecules, 2023; 28(3): 1329 / DOI: 10.3390/10.3390/molecules28031329
(6)
AP-1 pathway-targeted inhibition of inflammatory responses in LPS-treated macrophages and EtOH/HCl-treated stomach by Archidendron clypearia methanol extract / Woo Seok Yang, Deok Jeong, Gyeonsug Nam, Young-Su Yi, Jae Youl Cho et al / Journal of Ethnopharmacology, 2013; 146(2): pp 637-644 /
DOI: 10.1016/j.jep.2013.01.034
(7)
Src/NF-κB-targeted inhibition of LPS-induced macrophage activation and dextran sodium sulphate-induced colitis by Archidendron clypearia methanol extract / Woo Seok Yang, Jaehwi Lee, Jae Youl Cho et al / Journal of Ethnopharmacology, 2012; 142(1): pp 287-293 / DOI: 10.1016/j.jep.2012.04.026
(8)
Identification, characterization, kinetics, and molecular docking of flavonoid constituents from  Archidendron clypearia (Jack.) Nielsen leaves and twigs / Nguyen Phuong Thao, Bui Thi thuy Luyen, Young Ho Kim et al / Bioorganic & Medicinal Chemistry, 2016; 24(14): pp 3125-3132 /
DOI: 10.1016/j.bmc.2016.05.034
(9)
Triterpenes from Archidendron clypearia (Jack) I.C.N. with anti-β-amyloid aggregation activity  / Yu-Xi Wang, Zhi-Kang Duan, Ye Chang, Xiao-Xiao Huang et al / Natural Product Research, 2021; 35(16): pp 2789-2792 / DOI: 10.1080/14786419.2019.1666389
(10)
Phenolics from Archidendron clypearia (Jack) I.C.Nielsen protect SH-SY5Y cells against H2O2-induced oxidative stress / Yu-Xi Wang, Feng-Ying Han, Zhi-Kang Duan, Guo-Dong Yao, Shao-Jaing Song et al / Phytochemistry, 2020; Volume 176: 112414 / DOI: 10.1016/j.phytochem.2020.112414
(11)
A new dilignan from the twigs and leaves of Archidendron clypearia / Yu-Xi Wang, Zhi-Kang Duan, Shao-Jiang Song et al / Journal of Asian Natural Products Research, 2021; 23(6): pp 609-614 /
DOI: 10.1080/10286020.2020.1791097
(12)
AP-1 pathway-targeted inhibition of inflammatory responses in LPS-treated macrophages and EtOH/HCl-treated stomach by Archidendron clypearia methanol extract. / Yang WooSeok, Jeong Deok, Nam Gyeong Sug, Cho Jae Youl et al / Journal of Ethnopharmacology, 2013; 146(2): pp 637-644 / pISSN: 0378-8741 / DOI: 10.1016/j.jep.2013.01.034
(13)
Rat intestinal sucrase inhibited by minor constituents from the leaves and twigs of Archidendron clypearia(Jack.) Nielsen / Nguyen Phuong Thao, Bui Thi Thuy Luyen, Young Ho Kim et al / Bioorganic & Medicinal Chemistry Letters, 2016; 26(17): pp 4272-4276 / DOI: 10.1016/j.bmcl.2016.07.044
(14)
Study on antioxidant activities of the aerial partsand some compounds isolated from Archidendron clypearia (Jack) I. Niels Part 2. Isolating, determining structure and antioxidant capability of some compounds from ethyl acetate and chloroform extract / Le Trung Hieu, Vo Thi Mai Huong, Nguyen Thi Hoai, Tran Thi Van Thi /  Vietnam Journal of Science and Technology, 2016; 54(4) /
DOI: 10.15625/0866-708X/54/4/7394
(15)
Anti-β-amyloid aggregation activity of enantiomeric furolactone-type lignans from Archidendron clypearia(Jack) I.C.N. / Yu-Xi Wang, Bin Lin, Xiao-Xiao Huang et al / Natural Product Research, 2020; 34(4): pp 456-463 / DOI: 10.1080/14786419.2018.1488705
(16)
Archidendron clypearia / Biotik
(17)
Pithecellobium clypearia: Amelioration Effect on Imiquimod-Induced Psoriasis in Mice Based on a Tissue Metabonomic Analysis /  Ying Li, Jiiaxin Zong, Wenjun Ye, Yuanfeng Fu, Xinyi Gu, Mingmei Zhou et al / Front. Pharmacol.,, 2021; Sec. Ethnopharmacology, Volume 12 / DOI: 10.3389/fphar.2021.748772
(18)
Inhibitory Effects of Tea Leaf and Medicinal Plant Extracts on Enteric Pathogenic Bacteria Growth, Oxidation and Epithelial Cell Adhesion / Thida Kaewkod, Wilaiporn Songkhakul, Yingmanee Tragoolpua / Pharmacogn Res., 2022; 14(1): pp 71-81 / DOI: 10.5530/pres.14.1.11

DOI: It is not uncommon for links on studies/sources to change. Copying and pasting the information on the search window or using the DOI (if available) will often redirect to the new link page. (Citing and Using a (DOI) Digital Object Identifier)

                                                            List of Understudied Philippine Medicinal Plants
                                          New plant names needed
The compilation now numbers over 1,500 medicinal plants. While I believe there are hundreds more that can be added to the collection, they are becoming more difficult to find. If you have a plant to suggest for inclusion, native or introduced, please email the info: scientific name (most helpful), local plant name (if known), any known folkloric medicinal use, and, if possible, a photo. Your help will be greatly appreciated.

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