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Family Rubiaceae
Malakafe
Psydrax dicoccos Gaertn.
CEYLON BOX WOOD

Scientific names Common names
Canthium cymosum (Poir.) Pers. Bogas (P. Bis.)
Canthium dicoccum (Gaertn.) Merr. Luing-luing (P. Bis.)
Canthium didymum C.F.Gaertn. Malakafe (P. Bis.)
Canthium lucidulum (Miq.) Miq. Tandan (Mag.)
Canthium nitens DC. Ceylon boxwood (Engl.)
Canthium undulatum Champ. ex Benth.  
Cupia cymosa (Poir.) DC.  
Gardenia naumpapata Roxb. ex Wight & Arn.  
Gardenia sonneratii Spreng.  
Plectronia dicocca (Gaertn.) F.Muell.  
Plectronia didyma (C.F.Gaertn.) Bedd.  
Plectronia nitens (DC.) K.Schum.  
Polyozus bipinnata Lour.  
Psydrax dicoccos Gaertn.  
Rondeletia cymosa Poir.  
Vangueria dicocca (Gaertn.) Miq.  
Vangueria lucidula Miq.  
Vangueria spirostylis Miq.  
Webera cymosa Willd.  
Psydrax dicoccos Gaertn. is an accepted name The Plant List

Other vernacular names
INDIA: Tupa, Arsul, Earkolli maram, Erumbarathan.
KANNADA: Edrani.
TAMIL: Nallamandharam, Navugu, Naluvai, Nekkini. Irambaranthan.

Botany
Malakafe is an unarmed, smooth shrub 3 to 4 meters or more in height. Leaves are extremely variable, ovate, elliptic, ovate or somewhat rounded, 5 to 15 centimeters long, 1.5 to 10 centimeters wide, leathery, shining above, and usually pointed at both ends. Flowers are white, with very slender stalks, 5 to 10 millimeters long, and borne in compressed, short-stalked cymes. Calyx is cut off at the end or obscurely toothed. Corolla is bell-shaped, with a 4- to 6-millimeter tube, and five somewhat pointed lobes. Fruit is rounded, ellipsoid or obovoid, 6 to 10 millimeters long, slightly
flattened and obscurely 2-lobed.

Distribution
- In secondary and primary forests at low altitudes in Benguet, Pangasinan, Zambales, Bataan, Rizal and Batangas Provinces in Luzon; and in Mindoro, Ticao, Palawan, Negro, Guimaras, and Mindanao.
- Found from southeast China to tropical Asia.
- Listed as "vulnerable" in the IUCN Red List of Threatened Species.

Constituents
- Study yielded ursolic acid, rutin and 7-O-(5-O-benzoyl-ß-D-glucopyranosyl)-rutin.
- Study yielded major chemical components viz. Spathulenol (20.76 %), Caryophyllene oxide (19.25 %), Cedren-13-ol (10.62 %), Ledene oxide (5.24 %), m-mentho-4, 8-diene (6.41 %) and 2-furancarboxaldehyde (4.51 %). (See study below) (3)
- Various extracts of leaves yielded alkaloids, flavonoids, phenolic compounds, saponins, tannins, cardiac glycosides, steroids, and terpenoids. (see study below) (12)

Properties
- Febrifuge, antidiarrheal.
- Studies have suggested antifungal, antibacterial, anti-inflammatory, antidiabetic, anti-arthritic, nephroprotective, hepatoprotective properties.

Parts used
Bark, roots, leaves.

Uses

Edibility
- In India, fruit pulp reported as edible. (10)
Folkloric
- In India, bark is used for fever.
- Decoction of roots used for diarrhea.
- The Malayali tribals in Kolli hills of Tamil Nadu, India, a leaf extract mixed with banana is taken orally to facilitate delivery. (11)
Others
- Fish poison:
In India, coarsely ground plant parts used in small ponds and streams. (14)

Studies
Flavonol Glycoside:
Study yielded a new flavonol glycoside, 7-O-(5-O-benzoyl-ß-D-glucopyranosyl)-rutin. (1)
Antifungal:
Diglycosides, rutin and its benzoic derivative,
7-O-(5-O-benzoyl-ß-D-glucopyranosyl)-rutin from C dicoccum and kaempferol 3-ß-D-rutinoside from C rheedii strongly inhibited all test fungi. (2)
Anti-Inflammatory: Study evaluated an ethanolic extract of whole plant of Canthium diococcum for anti-inflammatory activity in Wistar albino rats in various models of anti-inflammatory activity viz., Carrageenan induced paw edema, Formalin induced paw edema, fresh egg white induced paw edema and cotton pellet induced granuloma model. Results showed the extract with anti-inflammatory activity and suggests a potential alternative to NSAIDS like diclofenac. (4)
Anti-Diabetic / Nephroprotective: Study evaluated an ethanolic extract of Canthium diococcum for anti-diabetic in an alloxan induced diabetic rat model. Results showed a significant drop in fasting blood sugar in a dose-dependent manner, with an effect on the beta-cell population in the pancreas. The extract showed almost equipotent antidiabetic activity compared to standard drug Glibenclamide. (5)
Anti-Arthritic: Study evaluated an ethanolic extract for anti-arthritic activity in albino rats. Results showed significant anti-arthritic activity against Egg-albumin induced arthritis model. (6)
Bioactive Components: Study of an ethanolic extract of leaf yielded major chemical constituents viz. Spathulenol (20.76 %), Caryophyllene oxide (19.25 %), Cedren-13-ol (10.62 %), Ledene oxide (5.24 %), m-mentho-4, 8-diene (6.41 %) and 2-furancarboxaldehyde (4.51 %). Some on the constituents provide scientific bases and evidence for antimicrobial, anti-tumor, immunomodulatory, and antioxidant properties of the plant. (3)
Hepatoprotective: Study evaluated an ethanolic extract of Canthium dicoccum whole plant for hepatoprotective activity in isoniazid (INH) and rifampicin (RIF) induced hepatotoxicity. Treatment with ECD significantly attenuated the INH and RIF induced enzyme elevations and improved serum T-PRO levels. (8)
Nephroprotective: Study evaluated the protective effect of aqueous extract of C. dicoccum against Streptomycin-induced nephrotoxicity in rats. Results suggest a dose-dependent nephroprotective potential as evidenced by improvement in biochemical and urinary parameters. (9)
Antibacterial / Antifungal: Study evaluated various solvent extracts for antimicrobial activity against Staphylococcus aureus, Streptococcus pyogenes, Enterococcus faecalis, E. coli, Proteus vulgaris, Pseudomonas aeruginosa, Vibrio cholerae, Candida albicans, C. parapsilosis, and C. tropicalis. A methanol extract showed the highest antimicrobial activity against all bacteria and fungal strains tested. (see constituents above) (12)
• Antifungal / Leaves: Study investigated the antifungal activity of methanol extract of leaves of Psydrax dicoccos against C. albicans C. krusei, C. guilliermondii, C. parapsilosis, C. tropicalis, C. glabrata, four dermatophytes viz., T. rubrum, T. mentagrophytes, M. gypseum and E. flococcum. The highest zone of inhibition was against C. albicans. Antifungal activity was attributed to cinnamic acid, 2H-1-Benzopyran-2-one, 5,7-, (Z)6,(Z)9-pentadecadien-1-ol, n-Hesadecanoic acid from the methanol extract. (13)
• Antioxidant Capacity / Free Radical Scavenging / Phenolic and Flavonoid Contents: Study evaluated the in vitro antioxidant activity of various extracts of Psydrax dicoccos using various radical scavenging assays. A methanol extract showed the highest phenol and flavonoid contents with total phenol content of 5.05 ± 0.76 mg/ml GAE/g and flavonoids of 6.72 ± 0.13 mg/ml QE/g. (14)

Availability
Wild-crafted.

© Godofredo U. Stuart Jr., M.D. / StuartXchange

Updated July 2018 / October 2016

IMAGE SOURCE: Photograph / File: Psydrax dicoccos 13.jpg / Forestowlet / 16 May 2017 / Creative Commons Attribution-Share Alike 4.0 / click on image to go to source page / Wikimedi Commons
OTHER IMAGE SOURCE: Line Drawing / Canthium dicoccum (Gaertn.) Teysmann et Binnedijk / Zhiwutong

Additional Sources and Suggested Readings
(1)
7-O-(6-O-Benzoyl-β- -glucopyranosyl)-rutin from leaves of Canthium dicoccum /
R. Gunasegaran, K. Subramani, P. Azantha Parimala et al / Fitoterapia, Vol 72, No 3, March 2001, Pages 201-205 / doi:10.1016/S0367-326X(00)00302-6
(2)
ANTIFUNGAL ACTIVITY OF THE CONSTITUENTS OF THE SPECIES OF CANTHIUM /
(3)
GC-MS Analysis of bioactive components from the ethanolic leaf extract of Canthium dicoccum (Gaertn.) Teijsm & Binn. / Raja Rajeswari. N, RamaLakshmi. S and Muthuchelian. K / J. Chem. Pharm. Res., 2011, 3(3):792-798
(4)
ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF CANTHIUM DICOCCUM / Bhaargavi Vuyyuri / INTERNATIONAL JOURNAL OF PHARMACEUTICAL AND PHYTOPHARMACOLOGICAL RESEARCH, Vol 3, No 3, 2013.
(5)
EVALUATION OF ANTI-DIABETIC AND NEPHRO PROTECTIVE ACTIVITY OF 95% ETHANOLIC EXTRACT OF CANTHIUM DICOCCUM WHOLE PLANT BY USING ALBINO RATS / SANTHAN S*, JANARTHAN M, ZUBER ALI M / Journal of Chemical and Pharmaceutical Sciences, Vol 6, No 4, Oct-Dec 2013
(6)
Evaluation of Anti-Arthritic Activity of Ethanolic Extract of Canthium diococcum in Albino Rats / B. Murali Reddy*, C.Stalin, E.Penchala Narasimhulu, V.Gunashekar / International Journal of Novel Prospects in Pharmaceutical Research
(7)
Psydrax dicoccus Gaertn. / Synonyms / The Plant List
(8)
Hepatoprotective Activity of Canthium dicoccum In Isoniazid and Rifampicin Induced Hepatotoxicity / Bhaargavi Vuyyuri*, Bhagyalakshmi A, Rajyalakshmi R, Jagadeeswari S / International Journal of Pharmaceutical and Clinical Research
(9)
INVESTIGATION OF AQUEOUS EXTRACT OF ROOTS OF CANTHIUM DICOCCUM IN STREPTOMYCIN INDUCED NEPHROTOXICITY IN ANIMAL MODEL / Malothu Nagulu*, T.Mangilal, R. Naga Kishore, G.Abhinayani and N.Sravya / World Journal of Pharmacy and Pharmaceutical Sciences, Vol 3, Issue 9, 314-320
(10)
Prospective wild edible fruit plants from part of northern Western Ghats (NWG), Mulshi (MS), India / Rani B Bhagat, Mahadev Chambhare, Sandip Mate, Amit Dudhale, BN Zaware / Journal of Medicinal Plants Studies 2016; 4(1): 15-19
(11)
Studies on ethnomedicinal plants used by malayali tribals in Kolli hills of Eastern ghats, Tamilnadu, India / Vaidyanathan D., M. S. Salai Senthilkumar and M. Ghouse Basha / Asian Journal of Plant Science and Research, 2013, 3(6):29-45
(12)
PHYTOCHEMICAL PROFILES, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF LEAVES FROM THE Psydrax dicoccos (Gaertn) / D. Umaiyambigai*, K. Saravanakumar and G. Adaikala Raj / Indo – Asian Journal of Multidisciplinary Research (IAJMR), Vol 2, Issue 1 (2016)
(13)
Phytochemical Profile and Antifungal Activity of Leaves Methanol Extract from the Psydrax dicoccos (Gaertn) Teys. & Binn. Rubiaceae Family / D Umaiyambigai, K Saravanakumar, Adaikala Raj / International Journal of Pharmacology, Phytochemistry, and Ethnomedicine, 2017; Vol 7: pp 53-61 /
DOI: 10.18052/www.scipress.com/IJPPE.7.53
(14)
Diversity and Traditional Uses of Some Poisonous Plants of Arunachal Pradesh / Bipul Ch. Kalita, Hui Tag, B.J. Gogoi and Pallabi K. Hui / IJARIIEm 2017; Vol 3, Issue 1

It is not uncommon for links on studies/sources to change. Copying and pasting the information on the search window or using the DOI (if available) will often redirect to the new link page.

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